(19)

(11)

EP 1 001 777 A1

(12)

(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98935967.4 (22) Date of filing: 23.07.1998

(51) International Patent Classification (IPC)7: A61K 31/495, C07D 237/00 (86) International application number: PCT/US9815/288 (87) International publication number: WO 9904/796 (04.02.1999 Gazette 1999/05)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 25.07.1997 US 53788 P 28.10.1997 US 63545 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HEERDING, Dirk Malvern, PA 19355 (US) SAMANEN, James, M. Phoenixville, PA 19460 (US) (74) Representative: Valentine, Jill Barbara et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)