(19)

(11)

EP 1 001 796 A1

(12)

(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98933290.3 (22) Date of filing: 08.07.1998

(51) International Patent Classification (IPC)7: A61K 35/78, A61K 38/48 // (A61K38/48, 33:10), A61K33:08,(A61K35/78, 33:10), A61K33:08 (86) International application number: PCT/US9814/233 (87) International publication number: WO 9903/486 (28.01.1999 Gazette 1999/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.07.1997 US 52543 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)	(72) Inventor: GEORGIADES, Constantine East Brunswick, NJ 08816 (US) (74) Representative: Mansmann, Ivo et al Warner-Lambert Company,Legal Division,Legal Department,c/o Gödecke AG 79090 Freiburg 79090 Freiburg (DE)