(19)

(11)

EP 1 001 983 A1

(12)

(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98937168.7 (22) Date of filing: 28.07.1998

(51) International Patent Classification (IPC)7: C07K 14/435, C07K 14/47, C07K 14/705, C12N 1/21, C12N 5/10, C12N 15/10, C12N 15/11 (86) International application number: PCT/US9815/539 (87) International publication number: WO 9905/170 (04.02.1999 Gazette 1999/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.07.1997 US 53869 P 30.07.1997 US 54210 P (71) Applicant: YALE UNIVERSITY New HavenCT 06520 (US)	(72) Inventors: DENTON, Rex Madison, CT 06443 (US) BARON, Roland GUILFORD, CT 06437 (US) (74) Representative: Doireau, Marc et al Cabinet Orès6, avenue de Messine 75008 Paris 75008 Paris (FR)