(19)

(11)

EP 1 002 104 A1

(12)

(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98943839.5 (22) Date of filing: 05.08.1998

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 9/64, A61K 38/48, C12Q 1/37, C07K 16/40, A61K 39/395, C12N 5/10, A61K 31/70, C12Q 1/68 (86) International application number: PCT/EP9804/859 (87) International publication number: WO 9907/856 (18.02.1999 Gazette 1999/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.08.1997 GB 9716755 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)	(72) Inventor: HOOFT VAN HUIJSDUINEN, Robertus, Antonius, Marie 1228 Plan les Ouates (CH) (74) Representative: Teuten, Andrew John et al Glaxo Wellcome plc,Glaxo Wellcome House,Berkeley Avenue Greenford,Middlesex UB6 0NN Greenford,Middlesex UB6 0NN (GB)