(19)

(11)

EP 1 002 119 A1

(12)

(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98937316.2 (22) Date of filing: 31.07.1998

(51) International Patent Classification (IPC)7: C12N 15/86, A61K 48/00 (86) International application number: PCT/US9816/051 (87) International publication number: WO 9906/583 (11.02.1999 Gazette 1999/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.07.1997 US 54329 P (71) Applicant: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION Pittsburgh, PA 15260 (US)	(72) Inventors: GLORIOSO, Joseph, C. Cheswick, PA 15024 (US) LAQUERRE, Sylvie Richmond, CA 94806 (US) (74) Representative: Wössner, Gottfried, Dr. Dipl.-Chem. et al Hoeger, Stellrecht & Partner,Uhlandstrasse 14c 70182 Stuttgart 70182 Stuttgart (DE)