(19)
(11) EP 1 003 521 A1

(12)

(43) Date of publication:
31.05.2000 Bulletin 2000/22

(21) Application number: 99914884.4

(22) Date of filing: 26.03.1999
(51) International Patent Classification (IPC)7: A61K 31/56, A61K 31/65, A61K 31/44, A61K 31/335, A61K 9/127
(86) International application number:
PCT/US9904/275
(87) International publication number:
WO 9949/869 (07.10.1999 Gazette 1999/40)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
SI

(30) Priority: 27.03.1998 US 79542 P

(71) Applicant: PHARMACIA & UPJOHN COMPANY
Kalamazoo,Michigan 49001 (US)

(72) Inventors:
  • KOPRESKI, Michael, S.
    Portage, MI 49024 (US)
  • ASP, Beryl
    S-254 76 Helsingborg (SE)
  • FREDHOLM, Bo
    S-254 84 Helsingborg (SE)
  • GUNNARSSON, Per-Olv
    S-252 51 Helsingborg (SE)

(74) Representative: Mazzini, Giuseppe 
Pharmacia & Upjohn S.p.A.Patents & Trademarks DepartmentViale Pasteur 10
20014 Nerviano (Milano)
20014 Nerviano (Milano) (IT)

   


(54) METHODS TO POTENTIATE INTRAVENOUS ESTRAMUSTINE PHOSPHATE