(19)

(11)

EP 1 003 543 A1

(12)

(43) Date of publication: 31.05.2000 Bulletin 2000/22 (21) Application number: 98923505.6 (22) Date of filing: 18.05.1998

(51) International Patent Classification (IPC)7: A61K 38/17, A61K 48/00, C12N 1/00, C12N 5/10, C12N 15/12, C12N 15/63, C12Q 1/37, C12Q 1/68 (86) International application number: PCT/US9810/181 (87) International publication number: WO 9852/597 (26.11.1998 Gazette 1998/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.05.1997 US 47080 P (71) Applicant: CHIRON CORPORATION EmeryvilleCalifornia 94608-2916 (US)	(72) Inventors: KOTHS, Kirston Emeryville, CA 94608-2916 (US) KOTHAKOTA, Srinivas Emeryville, CA 94608-2916 (US) WILLIAMS, Louis, T. Emeryville, CA 94608-2916 (US) REINHART, Christoph Emeryville, CA 94608-2916 (US) (74) Representative: Goldin, Douglas Michael et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)