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(11)

EP 1 003 715 A1

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(43) Date of publication: 31.05.2000 Bulletin 2000/22 (21) Application number: 98918385.0 (22) Date of filing: 21.04.1998

(51) International Patent Classification (IPC)7: C07C 237/10, C07C 211/14, C07C 323/41, A61K 31/16, A61K 31/13 (86) International application number: PCT/US9807/806 (87) International publication number: WO 9954/283 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicants: UNIVERSITE LAVAL Quebec,Quebec G1K 7P4 (CA) Ilex Oncology, Inc. San Antonio, TX 78230-1064 (US)	(72) Inventors: POULIN, Richard Ste-Foy, Québec G1Y 1S8 (CA) AUDETTE, Marie Cap-Rouge, Québec G1Y 3N1 (CA) CHAREST-GAUDREALT, René Bernières, Québec G7A 2N3 (CA) (74) Representative: Gowshall, Jonathan Vallance  FORRESTER & BOEHMERTFranz-Joseph-Strasse 38 80801 München 80801 München (DE)