(19)
(11) EP 1 003 740 A2

(12)

(88) Date of publication A3:
09.12.1999

(43) Date of publication:
31.05.2000 Bulletin 2000/22

(21) Application number: 98937139.8

(22) Date of filing: 27.07.1998
(51) International Patent Classification (IPC)7: C07D 405/00
(86) International application number:
PCT/US9815/479
(87) International publication number:
WO 9906/397 (11.02.1999 Gazette 1999/06)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
RO SI

(30) Priority: 04.08.1997 US 905913
27.03.1998 US 48955

(71) Applicant: Abbott Laboratories
Abbott Park,Illinois 60064-3500 (US)

(72) Inventors:
  • WINN, Martin
    Deerfield, IL 60015 (US)
  • BOYD, Steven, A.
    Mundelein, IL 60060 (US)
  • HUTCHINS, Charles, W.
    Gurnee, IL 60031 (US)
  • JAE, Hwan-Soo
    Glencoe, IL 60022 (US)
  • TASKER, Andrew, S.
    Gurnee, IL 60031 (US)
  • von GELDERN, Thomas, W.
    Richmond, IL 60071 (US)
  • KESTER, Jeffrey, A.
    Deerfield, IL 60015 (US)
  • SORENSEN, Bryan, K.
    Waukegan, IL 60087 (US)
  • SZCZEPANKIEWICZ, Bruce, G.
    Gages Lake, IL 60030 (US)
  • HENRY, Kenneth, J.
    Fishers, IN 46038 (US)
  • LIU, Gang
    Gurnee, IL 60031 (US)
  • WITTENBERGER, Steven, J.
    Mundelein, IL 60060 (US)
  • KING, Steven, A.
    Gurnee, IL 60031 (US)

(74) Representative: Modiano, Guido, Dr.-Ing. et al
Modiano, Josif, Pisanty & Staub,Baaderstrasse 3
80469 München
80469 München (DE)

   


(54) PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS