(19)
(11) EP 1 003 748 A2

(12)

(88) Date of publication A3:
27.05.1999

(43) Date of publication:
31.05.2000 Bulletin 2000/22

(21) Application number: 98951348.6

(22) Date of filing: 07.09.1998
(51) International Patent Classification (IPC)7: C07D 487/04, A61K 31/40, C07D 413/06, C07D 413/12
// (C07D487/04, 209:00), C07D209:00
(86) International application number:
PCT/EP9805/609
(87) International publication number:
WO 9912/933 (18.03.1999 Gazette 1999/11)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 09.09.1997 GB 9719183
09.09.1997 GB 9719189
10.09.1997 GB 9719290
21.02.1998 GB 9803611

(71) Applicant: GLAXO GROUP LIMITED
Greenford, Middlesex UB6 0NN (GB)

(72) Inventors:
  • CLARKE, Geoffrey, Duke, Edward
    StevenageHertfordshire SG1 2NY (GB)
  • DOWLE, Michael, Dennis
    StevenageHertfordshire SG1 2NY (GB)
  • FINCH, Harry
    StevenageHertfordshire SG1 2NY (GB)
  • HARRISON, Lee, Andrew
    StevenageHertfordshire SG1 2NY (GB)
  • INGLIS, Graham, George, Adam
    StevenageHertfordshire SG1 2NY (GB)
  • JOHNSON, Martin, Redpath
    StevenageHertfordshire SG1 2NY (GB)
  • MACDONALD, Simon, John, Fawcett
    StevenageHertfordshire SG1 2NY (GB)
  • SHAH, Pritom
    StevenageHertfordshire SG1 2NY (GB)
  • SMITH, Robin, Andrew
    StevenageHertfordshire SG1 2NY (GB)

(74) Representative: Teuten, Andrew John et al
Glaxo Wellcome plc,Glaxo Wellcome House,Berkeley Avenue
Greenford,Middlesex UB6 0NN
Greenford,Middlesex UB6 0NN (GB)

   


(54) PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE