(19)

(11)

EP 1 003 863 A1

(12)

(43) Date of publication: 31.05.2000 Bulletin 2000/22 (21) Application number: 98938144.7 (22) Date of filing: 30.07.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/715, C12N 15/62, G01N 33/566, C07K 16/28, C07K 16/42 (86) International application number: PCT/US9815/847 (87) International publication number: WO 9907/848 (18.02.1999 Gazette 1999/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.08.1997 US 906713 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: LOK, Si Seattle, WA 98107 (US) ADAMS, Robyn, L. Bellevue, WA 98007 (US) JELMBERG, Anna, C. Issaquah, WA 98027 (US) WHITEMORE, Theodore, E. Redmond, WA 98052 (US) FARRAH, Theresa, M. Seattle, WA 98122 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)