(19)
(11) EP 1 003 899 A1

(12)

(43) Date of publication:
31.05.2000 Bulletin 2000/22

(21) Application number: 98939015.8

(22) Date of filing: 11.08.1998
(51) International Patent Classification (IPC)7: C12N 15/90, C12N 15/55, C12N 9/22, C07K 14/435, A01K 67/027, A61K 48/00
(86) International application number:
PCT/NL9800/456
(87) International publication number:
WO 9907/871 (18.02.1999 Gazette 1999/07)
(84) Designated Contracting States:
BE CH DE ES FR GB IT LI LU NL

(30) Priority: 12.08.1997 US 909786

(71) Applicants:
  • Het Nederlands Kanker Instituut
    1066 CX Amsterdam (NL)
  • Introgene B.V.
    2333 AL Leiden (NL)

(72) Inventors:
  • VALERIO, Domenico
    NL-2314 EZ Leiden (NL)
  • SCHOUTEN, Govert, Johan
    NL-2321 AR Lieden (NL)
  • PLASTERK, Ronald, Hans, Anton
    NL-1405 AA Bussum (NL)
  • VAN LUENEN, Hendricus, Gerhard, Adrianus, Maria
    NL-1108 BM Amsterdam (NL)

(74) Representative: Ottevangers, Sietse Ulbe et al
Vereenigde,Postbus 87930
2508 DH Den Haag
2508 DH Den Haag (NL)

   


(54) VECTORS AND METHODS FOR PROVIDING CELLS WITH ADDITIONAL NUCLEIC ACID MATERIAL INTEGRATED IN THE GENOME OF SAID CELLS