(19)

(11)

EP 1 005 366 A1

(12)

(43) Date of publication: 07.06.2000 Bulletin 2000/23 (21) Application number: 98915130.3 (22) Date of filing: 26.02.1998

(51) International Patent Classification (IPC)7: A61K 39/29, C12N 1/15, C12N 1/21, C12N 5/10, C12N 5/14, C12N 5/16, C12Q 1/70 (86) International application number: PCT/US9804/428 (87) International publication number: WO 9839/031 (11.09.1998 Gazette 1998/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.03.1997 US 811566 (71) Applicant: WASHINGTON UNIVERSITY St. Louis, MO 63130 (US)	(72) Inventors: RICE, Charles, M., III University City, MO 63130 (US) KOLYKHALOV, Alexander A. St. Louis, MO 63139 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)