(19)

(11)

EP 1 005 367 A2

(12)

(88) Date of publication A3: 15.04.1999 (43) Date of publication: 07.06.2000 Bulletin 2000/23 (21) Application number: 98930917.4 (22) Date of filing: 22.06.1998

(51) International Patent Classification (IPC)7: A61K 39/385, A61K 39/10 // A61K39/095 (86) International application number: PCT/GB9801/819 (87) International publication number: WO 9858/668 (30.12.1998 Gazette 1998/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.06.1997 GB 9713156 (71) Applicant: Microbiological Research Authority Salisbury,Wiltshire SP4 0JG (GB)	(72) Inventors: FARRAR, Graham, Henry Salisbury,Wiltshire SP4 0JG (GB) JONES, David, Hugh Salisbury,Wiltshire SP4 0JG (GB) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)