(19)

(11)

EP 1 005 459 A1

(12)

(43) Date of publication: 07.06.2000 Bulletin 2000/23 (21) Application number: 98942869.3 (22) Date of filing: 09.09.1998

(51) International Patent Classification (IPC)7: C07D 217/04, C07D 217/02, A61K 31/47, C07D 401/12, C07D 413/12 (86) International application number: PCT/GB9802/728 (87) International publication number: WO 9914/197 (25.03.1999 Gazette 1999/12)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 12.09.1997 GB 9719530 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: THOMPSON, Mervyn,SmithKline Beecham Pharma. Harlow,Essex CM19 5AW (GB) PORTER, Roderick, A.,SmithKline Beecham Pharma. Welwyn,Hertfordshire AL6 9AR (GB) (74) Representative: West, Vivien et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)