(19)

(11)

EP 1 005 547 A1

(12)

(43) Date of publication: 07.06.2000 Bulletin 2000/23 (21) Application number: 98926445.2 (22) Date of filing: 08.06.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/435, C07K 16/18, G01N 33/566 // C07K14:325 (86) International application number: PCT/US9811/868 (87) International publication number: WO 9859/048 (30.12.1998 Gazette 1998/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.06.1997 US 880042 (71) Applicant: THE UNIVERSITY OF WYOMING Laramie, WY 82071 (US)	(72) Inventor: BULLA, Lee, A. Laramie, WY 82070 (US) (74) Representative: Gates, Marie Christina Esther  c/o Tomkins & Co.5 Dartmouth Road Dublin 6 Dublin 6 (IE)