(19)

(11)

EP 1 005 653 A1

(12)

(43) Date of publication: 07.06.2000 Bulletin 2000/23 (21) Application number: 98913043.0 (22) Date of filing: 24.03.1998

(51) International Patent Classification (IPC)7: G01N 33/566, G01N 33/551, G01N 33/552, G01N 33/544 (86) International application number: PCT/US9805/644 (87) International publication number: WO 9843/088 (01.10.1998 Gazette 1998/39)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 24.03.1997 US 41688 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventor: KAYNE, Paul, S. East Norriton, PA 19403 (US) (74) Representative: Connell, Anthony Christopher et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)