(19)

(11)

EP 1 006 999 A2

(12)

(88) Date of publication A3: 12.08.1999 (43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98933312.5 (22) Date of filing: 08.07.1998

(51) International Patent Classification (IPC)7: A61K 9/00 (86) International application number: PCT/US9814/310 (87) International publication number: WO 9902/132 (21.01.1999 Gazette 1999/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.07.1997 US 51944 05.08.1997 US 54756 (71) Applicant: Chiron Corporation Emeryville,California 94608 (US)	(72) Inventors: McCORMAK, James, E. San Diego, CA 92111 (US) JOLLY, Douglas, J. Encinitas, CA 92024 (US) VAN NEST, Gary Emeryville, CA 94608 (US) (74) Representative: Hallybone, Huw George et al CARPMAELS AND RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)