(19)
(11) EP 1 007 003 A1

(12)

(43) Date of publication:
14.06.2000 Bulletin 2000/24

(21) Application number: 97927989.0

(22) Date of filing: 10.06.1997
(51) International Patent Classification (IPC)7A61K 9/127, C07H 21/00, C12N 15/88
(86) International application number:
PCT/US9709/748
(87) International publication number:
WO 9813/026 (02.04.1998 Gazette 1998/13)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(71) Applicant: Genzyme Corporation
Framingham, MA 01701-9322 (US)

(72) Inventors:
  • MARSHALL, John
    Milford, MA 01757 (US)
  • HARRIS, David, J.
    Lexington, MA 02173 (US)
  • LEE, Edward, R.
    Quincy, MA 02169 (US)
  • SIEGEL, Craig, S.
    Woburn, MA 01801 (US)
  • EASTMAN, Simon, J.
    Marlboro, MA 01752 (US)
  • CHANG, Chau, Dung
    Lexington, MA 02173 (US)
  • SCHEULE, Ronald, K.
    Hopkinton, MA 01748 (US)
  • CHENG, Seng, H.
    Wellesley, MA 02181 (US)

(74) Representative: Froud, Clive et al
Elkington and FifeProspect House8 Pembroke Road
Sevenoaks, Kent TN13 1XR
Sevenoaks, Kent TN13 1XR (GB)

   


(54) CATIONIC AMPHIPHILE COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC MOLECULES