(19)

(11)

EP 1 007 038 A2

(12)

(88) Date of publication A3: 20.05.1999 (43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98938913.5 (22) Date of filing: 20.08.1998

(51) International Patent Classification (IPC)7: A61K 31/42, A61K 31/44 (86) International application number: PCT/JP9803/692 (87) International publication number: WO 9909/965 (04.03.1999 Gazette 1999/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.08.1997 JP 22530297 (71) Applicant: Takeda Chemical Industries, Ltd. Osaka-shi,Osaka 541-0045 (JP)	(72) Inventors: Odaka, Hiroyuki Kobe-shi,Hyogo 651-1223 (JP) Momose, Yu Takarazuka-shi,Hyogo 665-0847 (JP) (74) Representative: Lewin, John Harvey  Elkington and Fife,Prospect House,8 Pembroke Road Sevenoaks,Kent TN13 1XR Sevenoaks,Kent TN13 1XR (GB)