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EP 1 007 048 A1

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(43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98911551.4 (22) Date of filing: 11.03.1998

(51) International Patent Classification (IPC)7: A61K 31/54, A61K 38/17, A61K 49/00, A01N 37/12, A01N 37/18, A01N 43/00, A01N 43/32, A01N 43/38, A01N 43/40, A01N 43/60, A01N 59/08, A01N 59/26, C12Q 1/00, G01N 33/00, G01N 33/20, G01N 33/48, C07D 209/26, C07K 14/47 (86) International application number: PCT/US9804/683 (87) International publication number: WO 9840/071 (17.09.1998 Gazette 1998/37)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.03.1997 US 816122 (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US)	(72) Inventors: BUSH, Ashley, I. Somerville, MA 02143 (US) HUANG, Xudong Cambridge, MA 02140 (US) ATWOOD, Craig, S. Somerville, MA 02143 (US) TANZI, Rudolph, E. Hull, MA 02045 (US) (74) Representative: Lee, Nicholas John et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)