(19)

(11)

EP 1 007 069 A1

(12)

(43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 97911905.4 (22) Date of filing: 27.10.1997

(51) International Patent Classification (IPC)7: A61K 38/00, A61K 39/00, A61K 39/395, A61K 39/40, C07H 21/04, C07K 1/00, C12N 15/00, C12P 21/06, G01N 33/53 (86) International application number: PCT/US9719/226 (87) International publication number: WO 9819/689 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 01.11.1996 US 29930 P (71) Applicants: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US) SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)

(72) Inventors: BLACK, Michael, Terance Chester Springs, PA 19425 (US) HODGSON, John, Edward Malvern, PA 19355 (US) KNOWLES, David, Justin, Charles Redhill,Surrey RH1 6LY (GB) LONETTO, Michael, Arthur Collegeville, PA 19426 (US) NICHOLAS, Richard, Oakley Collegeville, PA 19426 (US) REID, Robert, H., Jr. East Norriton, PA 19401 (US) ZARFOS, Phillip, N. Norristown, PA 19403 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)