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(11)

EP 1 007 076 A1

(12)

(43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98910294.2 (22) Date of filing: 10.03.1998

(51) International Patent Classification (IPC)7: A61K 38/05, A01N 43/02, A01N 43/08, A01N 43/16, A01N 43/30 (86) International application number: PCT/US9804/699 (87) International publication number: WO 9840/093 (17.09.1998 Gazette 1998/37)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 10.03.1997 US 40658 P (71) Applicant: SMITHKLINE BECKMAN CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HOLT, Dennis, A. Stow, MA 01775 (US) VEBER, Daniel, F. Ambler, PA 19002 (US) YAMASHITA, Dennis, S. King of Prussia, PA 19406 (US) (74) Representative: Blakey, Alison Jane  Smithkline Beecham,Corporate Intellectual Property,Two New Horizons Court Brentford,Middlesex, TW8 9EP Brentford,Middlesex, TW8 9EP (GB)