(19)
(11) EP 1 007 526 A1

(12)

(43) Date of publication:
14.06.2000 Bulletin 2000/24

(21) Application number: 98943352.9

(22) Date of filing: 24.08.1998
(51) International Patent Classification (IPC)7: C07D 471/04, A61K 31/44
// (C07D471/04, 221:00), C07D221:00
(86) International application number:
PCT/US9817/513
(87) International publication number:
WO 9910/347 (04.03.1999 Gazette 1999/09)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 25.08.1997 US 918180

(71) Applicant: NEUROGEN CORPORATION
Branford, CT 06405 (US)

(72) Inventors:
  • ALBAUGH, Pamela
    Clinton, CT 06413 (US)
  • DeSIMONE, Robert, W.
    Durham, CT 06422 (US)
  • LIU, Gang
    Agoura, CA 91301 (US)

(74) Representative: Eyles, Christopher Thomas 
W.P. THOMPSON & CO.Celcon House289-293 High Holborn
London WC1V 7HU
London WC1V 7HU (GB)

   


(54) SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS