(19)

(11)

EP 1 007 660 A2

(12)

(88) Date of publication A3: 29.10.1998 (43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98901784.3 (22) Date of filing: 13.01.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 5/10, C07K 14/47, C12Q 1/68, A61K 38/17 (86) International application number: PCT/US9800/575 (87) International publication number: WO 9830/696 (16.07.1998 Gazette 1998/28)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.01.1997 US 783395 04.04.1997 WO PCT/US97/05682 30.05.1997 US 866022 05.09.1997 US 924838 12.01.1998 US 5986 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)	(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) MCCOY, John, M. Reading, MA 01867 (US) LAVALLIE, Edward, R. Tewksbury, MA 01876 (US) RACIE, Lisa, A. Acton, MA 01720 (US) MERBERG, David Acton, MA 01720 (US) AGOSTINO, Michael, J. Andover, MA 01810 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)