(19)
(11) EP 1 007 662 A1

(12)

(43) Date of publication:
14.06.2000 Bulletin 2000/24

(21) Application number: 98902970.7

(22) Date of filing: 20.02.1998
(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 15/85, A61K 48/00
(86) International application number:
PCT/DK9800/068
(87) International publication number:
WO 9837/190 (27.08.1998 Gazette 1998/34)
(84) Designated Contracting States:
AT BE CH DE ES FR GB IE IT LI NL

(30) Priority: 20.02.1997 DK 18397
28.08.1997 US 919226

(71) Applicants:
  • Strauss, Michael
    1418 Copenhagen K (DK)
  • Sandig, Volker
    13125 Berlin (DE)
  • Bartek, Jiri
    2650 Greve (DK)
  • Lukas, Jiri
    2650 Greve (DK)
  • Hepavec AG fur Gentherapie
    13125 Berlin (DE)

(72) Inventors:
  • Strauss, Michael
    1418 Copenhagen K (DK)
  • Sandig, Volker
    13125 Berlin (DE)
  • Bartek, Jiri
    2650 Greve (DK)
  • Lukas, Jiri
    2650 Greve (DK)
  • Hepavec AG fur Gentherapie
    13125 Berlin (DE)

(74) Representative: Weiss, Wolfgang, Dipl.-Chem. Dr. et al
Postfach 86 08 20
81635 München
81635 München (DE)

   


(54) METHOD FOR INDUCTION OF APOPTOTIC CELL DEATH IN MALIGNANT CELLS, THROUGH REDUCTION OF THE RB TO APOPTOSIS INDUCING PROTEINS RATIO