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EP 1 007 667 A1

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(43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98908674.9 (22) Date of filing: 17.02.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/28, C07K 14/705, C12N 5/10, C12N 5/16, A61K 39/00, G01N 33/50, A61K 39/395, C12N 15/62 (86) International application number: PCT/US9803/513 (87) International publication number: WO 9836/073 (20.08.1998 Gazette 1998/33)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.02.1997 US 3513 P (71) Applicant: Reprogen, Inc. Irvine, CA 92618 (US)	(72) Inventors: FRENCH, Cynthia, K. Irvine, CA 92612 (US) NEILSON, Lorna, I. Vista, CA 92083 (US) SCHNEIDER, Patrick, A. Irvine, CA 92620 (US) YAMAMOTO, Karen, K. San Clemente, CA 92672 (US) (74) Representative: Bizley, Richard Edward  Hepworth, Lawrence, Bryer & BizleyMerlin HouseFalconry CourtBaker's Lane EppingEssex CM16 5DQ EppingEssex CM16 5DQ (GB)