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(11)

EP 1 007 735 A1

(12)

(43) Date of publication: 14.06.2000 Bulletin 2000/24 (21) Application number: 98911409.5 (22) Date of filing: 24.02.1998

(51) International Patent Classification (IPC)7: C12Q 1/68, C12N 15/00, C12N 15/64, C12P 19/34, C07H 21/00, C07H 21/02, C07H 21/04, A61K 48/00 (86) International application number: PCT/US9803/636 (87) International publication number: WO 9837/240 (27.08.1998 Gazette 1998/34)

(84) Designated Contracting States: DE FR GB (30) Priority: 24.02.1997 US 38797 P (71) Applicant: TM Technologies Inc. Woburn, MA 01801 (US)	(72) Inventors: LANE, Michael, J. Baldwinsville, NY 13027 (US) BENIGHT, Albert, S. Schaumburg, IL 60193 (US) FALDASZ, Brian, D. Maynard, MA 01754 (US) MACADAM, Don Port DoverOntario N0A 1N0 (CA) (74) Representative: White, Martin Paul et al Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)