(19)

(11)

EP 1 009 236 A1

(12)

(43) Date of publication: 21.06.2000 Bulletin 2000/25 (21) Application number: 98934656.4 (22) Date of filing: 20.07.1998

(51) International Patent Classification (IPC)7: A01N 63/00, A01N 43/04, C12Q 1/68, C12N 15/64, C12N 5/00, C07H 21/04 (86) International application number: PCT/US9814/968 (87) International publication number: WO 9904/636 (04.02.1999 Gazette 1999/05)

(84) Designated Contracting States: CH DE ES FR GB LI (30) Priority: 22.07.1997 US 53356 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US)	(72) Inventors: HAJJAR, Roger, J. Cambridge, MA 02141 (US) ROSENZWEIG, Anthony Newton, MA 02168 (US) GUERRERO, Luis Norton, MA 02766 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)