(19)

(11)

EP 1 009 433 A1

(12)

(43) Date of publication: 21.06.2000 Bulletin 2000/25 (21) Application number: 98931277.2 (22) Date of filing: 16.06.1998

(51) International Patent Classification (IPC)7: A61K 39/395 (86) International application number: PCT/US9812/401 (87) International publication number: WO 9857/661 (23.12.1998 Gazette 1998/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.06.1997 US 877511 (71) Applicant: Altarex Corp. Waltham, MA 02154 (US)	(72) Inventors: SYKES, Thomas, R. Edmonton, Alberta T6R 2M5 (CA) MADIYALAKAN, Ragupathy Cambridge, MA 02138 (US) BAUM, Richard, P. D-60590 Frankfurt (DE) NOUJAIM, Antoine, A. Edmonton, Alberta T6M 3KA (CA) (74) Representative: Grund, Martin, Dr. et al Holbeinstrasse 5 81679 München 81679 München (DE)