(19)

(11)

EP 1 009 443 A1

(12)

(43) Date of publication: 21.06.2000 Bulletin 2000/25 (21) Application number: 98942175.5 (22) Date of filing: 21.08.1998

(51) International Patent Classification (IPC)7: A61K 48/00, C07H 21/02, C07H 21/04, C12N 15/00, C12N 15/63, C12N 15/85, C12N 15/86, C12P 21/00 (86) International application number: PCT/US9817/324 (87) International publication number: WO 9910/012 (04.03.1999 Gazette 1999/09)

(84) Designated Contracting States: BE CH CY DE DK FR GB IT LI NL (30) Priority: 25.08.1997 US 56939 P (71) Applicant: Smithkline Beecham Philadelphia, PA 19103 (US)	(72) Inventor: WARREN, Richard, L. Blue Bell, PA 19422 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)