(19)

(11)

EP 1 009 444 A2

(12)

(88) Date of publication A3: 01.07.1999 (43) Date of publication: 21.06.2000 Bulletin 2000/25 (21) Application number: 98945862.5 (22) Date of filing: 02.09.1998

(51) International Patent Classification (IPC)7: A61K 48/00, C12N 15/48 (86) International application number: PCT/US9818/308 (87) International publication number: WO 9911/292 (11.03.1999 Gazette 1999/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.09.1997 US 56039 P (71) Applicant: Chiron Corporation Emeryville,California 94608-2917 (US)	(72) Inventors: McCORMACK, James, E. San Diego, CA 92111 (US) CHADA, Sunil Vista, CA 92083 (US) JOLLY, Douglas, J. Leucadia, CA 92024 (US) (74) Representative: Hallybone, Huw George et al CARPMAELS AND RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)