(19)

(11)

EP 1 009 518 A1

(12)

(43) Date of publication: 21.06.2000 Bulletin 2000/25 (21) Application number: 98922038.9 (22) Date of filing: 16.04.1998

(51) International Patent Classification (IPC)7: B01F 3/04 (86) International application number: PCT/US9807/671 (87) International publication number: WO 9846/340 (22.10.1998 Gazette 1998/42)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 16.04.1997 US 840908 (71) Applicant: WAYNE STATE UNIVERSITY Detroit, MI 48202 (US)	(72) Inventors: SPEARS, J., Richard Bloomfield Hills, MI 48304 (US) CRILLY, Richard, J. Windsor, Ontario N9G 1V3 (CA) (74) Representative: Brunner, Michael John  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)