(19)
(11) EP 1 009 736 A1

(12)

(43) Date of publication:
21.06.2000 Bulletin 2000/25

(21) Application number: 98951320.5

(22) Date of filing: 27.08.1998
(51) International Patent Classification (IPC)7: C07C 259/06, A61K 31/185
(86) International application number:
PCT/EP9805/441
(87) International publication number:
WO 9911/608 (11.03.1999 Gazette 1999/10)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 01.09.1997 EP 97115086

(71) Applicant: Roche Diagnostics GmbH
68298 Mannheim (DE)

(72) Inventors:
  • GRAMS, Frank
    D-68219 Mannheim (DE)
  • MORODER, Luis
    D-82152 Martinsried (DE)
  • GRAF VON RÖDERN, Erich
    D-63628 Bad Soden-Salmünster (DE)

   


(54) MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS