(19)

(11)

EP 1 011 330 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98943195.2 (22) Date of filing: 12.08.1998

(51) International Patent Classification (IPC)7: A01N 63/00, C12N 15/64, C12N 5/00, A61K 38/00, A01N 43/04 (86) International application number: PCT/US9816/794 (87) International publication number: WO 9908/533 (25.02.1999 Gazette 1999/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.08.1997 US 55268 P (71) Applicant: Yale University New Haven, CT 06520-8336 (US)	(72) Inventor: STRITTMATTER, Stephen, M. Clinton, CT 06413 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)