(19)

(11)

EP 1 011 410 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 97942495.9 (22) Date of filing: 11.09.1997

(51) International Patent Classification (IPC)7: A61B 1/00 (86) International application number: PCT/US9716/373 (87) International publication number: WO 9810/695 (19.03.1998 Gazette 1998/11)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.09.1996 US 713924 (71) Applicant: Genzyme Corporation Framingham, MA 01701-9322 (US)	(72) Inventors: WELLS, B., Keith Marietta, GA 30067 (US) MAYFIELD, William, R. Atlanta, GA 30327 (US) FURNISH, Gregory, R. Louisville, KY 40207 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)