(19)

(11)

EP 1 011 665 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98906687.3 (22) Date of filing: 26.02.1998

(51) International Patent Classification (IPC)7: A61K 31/40, A61K 31/445, A61K 31/495, A61K 31/535, C07D 401/00, C07D 403/00, C07D 413/00, C07D 491/02 (86) International application number: PCT/US9803/612 (87) International publication number: WO 9840/068 (17.09.1998 Gazette 1998/37)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 10.03.1997 US 40265 P 26.03.1997 GB 9706304 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: MOHAMADI, Fariborz Lake Forrest, IL 60045 (US) PATEL, Vinod, F. Carmel, IN 46032 (US) (74) Representative: Vaughan, Jennifer Ann  Lilly Research Centre,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)