(19)

(11)

EP 1 011 680 A2

(12)

(88) Date of publication A3: 06.05.1999 (43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98941610.2 (22) Date of filing: 07.09.1998

(51) International Patent Classification (IPC)7: A61K 31/55, A61K 9/16, A61K 47/12 (86) International application number: PCT/GB9802/692 (87) International publication number: WO 9912/549 (18.03.1999 Gazette 1999/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.09.1997 GB 9718986 (71) Applicant: West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Nottingham NG7 2TN (GB)	(72) Inventors: ILLUM, Lisbeth The ParkNottingham NG7 1BA (GB) CHENG, Yu-Hui BeestonNottingham NG9 2PR (GB) WATTS, Peter, James West BridgfordNottingham NG2 6DR (GB) DAVIS, Stanley, Stewart The ParkNottingham NG7 1BA (GB) (74) Representative: McNeeney, Stephen Phillip et al Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)