PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- 1- 3- (AMINOIMINOMETHYL)AMINO]PROPYL]-3,3-DIFLUORO-2-OXOHEXYL]-L-PROLINAMIDE - Patent 1012165

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(11)

EP 1 012 165 A1

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(43)	Date of publication:
	28.06.2000 Bulletin 2000/26

(21)	Application number: 97908712.9

(22)	Date of filing: 25.02.1997

(51)	International Patent Classification (IPC)⁷: C07K 5/06, C07C 277/08

(86)	International application number:
	PCT/US9702/869

(87)	International publication number:
	WO 9735/874 (02.10.1997 Gazette 1997/42)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV RO SI

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Priority:

26.03.1996 US 624721

(71)	Applicant: Aventis Pharmaceuticals Inc.
	Bridgewater, NJ 08807-0800 (US)

(72)	Inventor:
	RUDISILL, Duane, E. West Chester, OH 45069 (US)

(74)	Representative: Macchetta, Francesco et al
	GRUPPO LEPETIT S.p.A.,Patent Department,Piazza Türr 5 20149 Milano 20149 Milano (IT)

(54)	PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- 1- 3- (AMINOIMINOMETHYL)AMINO]PROPYL]-3,3-DIFLUORO-2-OXOHEXYL]-L-PROLINAMIDE