(19)

(11)

EP 1 012 233 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 97931220.4 (22) Date of filing: 17.06.1997

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 15/00, A61K 38/00, A61K 38/24 (86) International application number: PCT/US9710/489 (87) International publication number: WO 9858/051 (23.12.1998 Gazette 1998/51)

(84) Designated Contracting States: BE CH DE FR GB LI NL SE (71) Applicant: GENZYME TRANSGENICS CORPORATION Framingham, MA 01701 (US)	(72) Inventors: ECHELARD, Yann Brookline, MA 02146 (US) WILBURN, Brian Everett, MA 02149 (US) (74) Representative: Ruffles, Graham Keith et al MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)