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(11)

EP 1 012 260 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98936854.3 (22) Date of filing: 15.07.1998

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/11, C12N 15/19, C12N 15/03, C12N 15/74, C12N 15/63, C12N 5/00, C07K 14/54, C07K 16/24, A61K 38/20 (86) International application number: PCT/US9814/609 (87) International publication number: WO 9903/982 (28.01.1999 Gazette 1999/04)

(84) Designated Contracting States: FR (30) Priority: 16.07.1997 US 52870 P 26.09.1997 US 60140 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: RUBEN, Steven, M. Olney, MD 20832 (US) EBNER, Reinhard Gaithersburg, MD 20878 (US) DUAN, Roxanne, D. Bethesda, MD 20817 (US) FLORENCE, Kimberly, A. Rockville, MD 20851 (US) HU, Jing-Shan Sunnyvale, CA 94086 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)