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EP 1 012 261 A1

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(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98939877.1 (22) Date of filing: 06.08.1998

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/11, C12N 1/21, C12N 15/63, C07H 21/02, C07H 21/04, C07K 14/00, A61K 38/00 (86) International application number: PCT/US9816/318 (87) International publication number: WO 9907/840 (18.02.1999 Gazette 1999/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.08.1997 US 906708 04.08.1998 US 130189 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)

(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) MCCOY, John, M. Reading, MA 01867 (US) LAVALLIE, Edward, R. Harvard, MA 01451 (US) RACIE, Lisa, A. Acton, MA 01720 (US) EVANS, Cheryl Woburn, MA 01801 (US) MERBERG, David Acton, MA 01720 (US) TREACY, Maurice Chestnut Hill, MA 02167 (US) AGOSTINO, Michael, J., II Andover, MA 01810 (US) STEININGER, Robert, J., II Cambridge, MA 02140 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)