(19)

(11)

EP 1 012 270 A2

(12)

(88) Date of publication A3: 27.05.1999 (43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98946052.2 (22) Date of filing: 11.09.1998

(51) International Patent Classification (IPC)7: C12N 15/11, C07K 14/525, A61K 38/00 (86) International application number: PCT/US9819/037 (87) International publication number: WO 9912/964 (18.03.1999 Gazette 1999/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.09.1997 US 58786 P (71) Applicant: Apotech R&D S.A. 1204 Genève (CH)	(72) Inventor: TSCHOPP, Jurg CH-1066 Epalinges (CH) (74) Representative: Helbing, Jörg, Dr. Dipl.-Chem. et al Patentanwältevon Kreisler-Selting-Werner,Postfach 10 22 41 50462 Köln 50462 Köln (DE)