(19)

(11)

EP 1 012 292 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98925109.5 (22) Date of filing: 03.06.1998

(51) International Patent Classification (IPC)7: C12N 15/19, C07K 14/52, C07K 16/24, C07K 19/00, A61K 38/19, C12Q 1/68, A61K 39/395 (86) International application number: PCT/US9811/153 (87) International publication number: WO 9855/620 (10.12.1998 Gazette 1998/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.06.1997 US 48776 P 21.11.1997 US 66386 P (71) Applicant: REGENERON PHARMACEUTICALS, INC. Tarrytown, NY 10591-6707 (US)	(72) Inventors: MASIAKOWSKI, Piotr Pleasant Valley, NY 12569 (US) VALENZUELA, David Franklin Square, NY 11010 (US) (74) Representative: Goldin, Douglas Michael et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)