(19)

(11)

EP 1 012 296 A2

(12)

(88) Date of publication A3: 05.11.1998 (43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98901415.4 (22) Date of filing: 28.01.1998

(51) International Patent Classification (IPC)7: C12N 15/53, C12N 15/85, C12N 9/02, C12N 15/70, C12N 5/10, A61K 38/44, C12N 1/21, G01N 33/68, C07K 16/40, C12Q 1/68, A01K 67/027 (86) International application number: PCT/GB9800/263 (87) International publication number: WO 9832/863 (30.07.1998 Gazette 1998/30)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.01.1997 GB 9701710 (71) Applicant: KARO BIO AB 141 57 Huddinge (SE)	(72) Inventor: SPYROU, Giannis,Karolinska Institutet S-141 57 Huddinge (SE) (74) Representative: Dean, John Paul et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)