(19)

(11)

EP 1 012 315 A1

(12)

(43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 97922279.1 (22) Date of filing: 07.05.1997

(51) International Patent Classification (IPC)7: C12N 15/70, C12N 15/74 // C07K14/01 (86) International application number: PCT/SE9700/763 (87) International publication number: WO 9803/666 (29.01.1998 Gazette 1998/04)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV RO SI (30) Priority: 18.07.1996 SE 9602803 10.09.1996 SE 9603282 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventor: SHARMA, Umender Bangalore 560003,Karnataka State (IN)