(19)

(11)

EP 1 012 321 A2

(12)

(88) Date of publication A3: 17.06.1999 (43) Date of publication: 28.06.2000 Bulletin 2000/26 (21) Application number: 98942892.5 (22) Date of filing: 11.09.1998

(51) International Patent Classification (IPC)7: C12N 15/86, C07K 14/47, A61K 48/00, A61K 38/16, A61K 38/17, C12N 5/08, C12N 5/10, C12N 5/12 (86) International application number: PCT/GB9802/753 (87) International publication number: WO 9913/064 (18.03.1999 Gazette 1999/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.09.1997 GB 9719238 (71) Applicant: THE MATHILDA AND TERENCE KENNEDY INSTITUTE OF RHEUMATOLOGY London W6 8LH (GB)	(72) Inventors: FELDMANN, Marc London N6 4QT (GB) FOXWELL, Brian, Maurice, John Hounslow,Middlesex TW3 1LQ (GB) BRENNAN, Fionula, Mary Teddington,Middlesex TW11 0RL (GB) BONDESON, Jan London SW6 6TL (GB) (74) Representative: Bannerman, David Gardner et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)