(19)

(11)

EP 1 014 970 A1

(12)

(43) Date of publication: 05.07.2000 Bulletin 2000/27 (21) Application number: 98951367.6 (22) Date of filing: 04.09.1998

(51) International Patent Classification (IPC)7: A61K 31/35, A61K 31/365, A61K 9/00, A61K 9/20 (86) International application number: PCT/EP9805/720 (87) International publication number: WO 9915/166 (01.04.1999 Gazette 1999/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 23.09.1997 GB 9720228 12.05.1998 GB 9810143 (71) Applicants: Pfizer Limited SandwichKent CT13 9NJ (GB) GB  PFIZER INC. New York, N.Y. 10017 (US) BE CH DE DK ES FI FR GR IE IT LI LU NL PT SE AT CY	(72) Inventor: HUATAN, Hiep,Pfizer Central Research Sandwich,Kent CT13 9NJ (GB) (74) Representative: Hayles, James Richard et al Pfizer Limited,Patents Department,Ramsgate Road SandwichKent CT13 9NJ SandwichKent CT13 9NJ (GB)