(19)

(11)

EP 1 014 972 A1

(12)

(43) Date of publication: 05.07.2000 Bulletin 2000/27 (21) Application number: 97905757.7 (22) Date of filing: 04.02.1997

(51) International Patent Classification (IPC)7: A61K 31/41, A61K 31/44, A61K 31/47, A61K 31/405 (86) International application number: PCT/US9701/799 (87) International publication number: WO 9728/797 (14.08.1997 Gazette 1997/35)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO SI (30) Priority: 08.02.1996 US 11328 P 29.04.1996 GB 9608927 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: DAHLEN, Sven-Erik Rahway, NJ 07065 (US) SCOLNICK, Edward, M. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)