(19)

(11)

EP 1 014 973 A1

(12)

(43) Date of publication: 05.07.2000 Bulletin 2000/27 (21) Application number: 98931320.0 (22) Date of filing: 17.06.1998

(51) International Patent Classification (IPC)7: A61K 31/415, A61K 31/42, A61K 31/425, A61K 31/505, A61K 31/275, C07D 239/34, C07D 491/08, C07D 487/04, C07D 233/02, C07D 263/04, C07D 275/02, C07D 277/04, C07C 255/00 (86) International application number: PCT/US9812/573 (87) International publication number: WO 9857/632 (23.12.1998 Gazette 1998/51)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 18.06.1997 US 50136 P 07.01.1998 GB 9800219 (71) Applicants: MERCK & CO., INC. Rahway, New Jersey 07065 (US) SYNAPTIC PHARMACEUTICAL CORPORATION Paramus,New Jersey 07652-1410 (US)	(72) Inventors: PATANE, Michael, A. Rahway, NJ 07065 (US) BOCK, Mark, G. Rahway, NJ 07065 (US) NAGARATHNAM, Dhanapalan Paramus, NJ 07652 (US) LAGU, Bharat Paramus, NJ 07652 (US) WONG, Wai, C. Paramus, NJ 07652 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)